Arizona Cardinals Vs San Francisco 49ers: Week 9 NFL Betting Preview And Insights – November 7, 2021

Written By Staff on November 7, 2021 - Last Updated on July 14, 2022

The Arizona Cardinals (7-1) visit the San Francisco 49ers (3-4) on Sunday, November 7, 2021 in matchup between NFC West foes at Levi’s Stadium. San Francisco is a 2.5-point underdog. The over/under is set at 46 points for the outing.

Betting Odds

Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds
Cardinals -2.5 -115 -105 46 -110 -110

The betting insights in this article reflect betting data from DraftKings as of November 1, 2021, 12:00 AM ET. CLICK HERE to find current betting odds and place a bet at DraftKings Sportsbook.

Cardinals Leaders

  • Kyler Murray has passed for 2,276 yards (186-for-256), with 17 touchdowns and seven interceptions (284.5 YPG). He’s also rushed 49 times for 147 yards and three touchdowns.
  • Chase Edmonds has churned out a team-leading 427 rushing yards (53.4 per game) plus one touchdown. He has tacked on 30 catches for 211 yards .
  • DeAndre Hopkins has reeled in 35 passes for a team-high 486 yards plus seven touchdowns. He averages 60.8 receiving yards per game.
  • Murray is the No. 5 fantasy player overall and the No. 5 fantasy quarterback with 177.7 points (averaging 22.2 per game).
  • Hopkins’ 90.6 total fantasy points (an average of 11.3 per game), are good enough to rank him 49th overall and 10th among receivers.

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Cardinals Injuries

Cardinals: No Injuries Listed

Head To Head

Cardinals vs 49ers: Last 4 Meetings
Date Favorite Home Team Spread Total Favorite Moneyline Underdog Moneyline Total Yards Result
12/26/2020 Cardinals Cardinals -5.5 49 -265 +215 398-350 SF 20-12 SF
9/13/2020 49ers 49ers -6.5 48 -295 +255 404-366 ARI 24-20 ARI
11/17/2019 N/A 49ers N/A N/A N/A N/A 442-266 SF 36-26 SF
10/31/2019 N/A Cardinals N/A N/A N/A N/A 411-357 SF 28-25 SF

Cardinals Insights

  • The Cardinals have averaged 6.4 more points scored this season (30.8) than the 49ers have allowed (24.4).
  • When it exceeds what San Francisco gives up this season (24.4 points per game), Arizona is 6-0 and 5-1 against the spread.
  • When San Francisco limits opposing offenses to less than 30.8 points, it is 2-4 overall and 3-4 against the spread.
  • The 49ers have allowed opposing rushing attacks to average 127.1 yards per game in 2021 compared to the 128.8 yards the Cardinals offense has averaged on the ground per contest.
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Cardinals Schedule

Date Opponent Score Home/Away Spread
9/12/2021 Titans W 38-13 Away +2.5
9/19/2021 Vikings W 34-33 Home -3.5
9/26/2021 Jaguars W 31-19 Away -8
10/3/2021 Rams W 37-20 Away +4
10/10/2021 49ers W 17-10 Home -5.5
10/17/2021 Browns W 37-14 Away +3
10/24/2021 Texans W 31-5 Home -17.5
10/28/2021 Packers L 24-21 Home -6.5
11/7/2021 49ers Away -2.5
11/14/2021 Panthers Home
11/21/2021 Seahawks Away
12/5/2021 Bears Away
12/13/2021 Rams Home
12/19/2021 Lions Away
12/25/2021 Colts Home
1/2/2022 Cowboys Away
1/9/2022 Seahawks Home

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