Arizona Cardinals Vs San Francisco 49ers: Week 5 NFL Betting Preview And Insights – October 10, 2021

Written By Staff on October 5, 2021

The Arizona Cardinals (4-0) are favored by 5.5 points as they try to keep their four-game winning streak alive in a matchup with the San Francisco 49ers (2-2) on Sunday, October 10, 2021 at State Farm Stadium. The contest has a point total set at 49.5.

Betting Odds

Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds
Cardinals -5.5 -115 -105 49.5 -110 -110

The betting insights in this article reflect betting data from DraftKings as of October 4, 2021, 12:00 AM ET. CLICK HERE to find current betting odds and place a bet at DraftKings Sportsbook.

Cardinals Leaders

  • Kyler Murray has thrown for 1,273 yards while connecting on 76.1% of his passes (102-for-134), with nine touchdowns and four interceptions (318.3 yards per game). He’s also run the ball 23 times for 109 yards and three touchdowns.
  • Chase Edmonds has churned out a team-best 255 rushing yards (63.8 per game). He has added 20 catches for 140 yards .
  • A.J. Green has 15 catches (on 24 targets) and leads the team with 248 receiving yards (62 per game) while hauling in two touchdowns.
  • Murray is the No. 2 fantasy player overall and the No. 2 fantasy quarterback with 107.8 points (averaging 27 per game).
  • James Conner has recorded 43.8 fantasy points this year (11 per game), enough to rank him 59th overall and 17th among running backs in league-wide fantasy standings.

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Cardinals Injuries

Cardinals: No Injuries Listed

Head To Head

Cardinals vs 49ers: Last 4 Meetings
Date Favorite Home Team Spread Total Favorite Moneyline Underdog Moneyline Total Yards Result
12/26/2020 Cardinals Cardinals -5.5 49 -265 +215 398-350 SF 20-12 SF
9/13/2020 49ers 49ers -6.5 48 -295 +255 404-366 ARI 24-20 ARI
11/17/2019 N/A 49ers N/A N/A N/A N/A 442-266 SF 36-26 SF
10/31/2019 N/A Cardinals N/A N/A N/A N/A 411-357 SF 28-25 SF

Cardinals Insights

  • The Cardinals have scored 35 points per game this season, 9.5 more than the 49ers have given up.
  • In games where Arizona scores more than 25.5 points, it is 4-0 overall and 3-1 against the spread.
  • When the San Francisco defense allows less than 35 points the 49ers have put together a 2-2 overall record and a 1-3 record against the spread.
  • The 49ers are conceding 118 yards per game on the ground, compared to the 136.5 rushing yards the Cardinals are accumulating.
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Cardinals Schedule

Date Opponent Score Home/Away Spread
9/12/2021 Titans W 38-13 Away +2.5
9/19/2021 Vikings W 34-33 Home -3.5
9/26/2021 Jaguars W 31-19 Away -8
10/3/2021 Rams W 37-20 Away +4
10/10/2021 49ers Home -5.5
10/17/2021 Browns Away
10/24/2021 Texans Home
10/28/2021 Packers Home
11/7/2021 49ers Away
11/14/2021 Panthers Home
11/21/2021 Seahawks Away
12/5/2021 Bears Away
12/13/2021 Rams Home
12/19/2021 Lions Away
12/25/2021 Colts Home
1/2/2022 Cowboys Away
1/9/2022 Seahawks Home

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